Zona pellucida from fertilised human oocytes induces a voltage-dependent calcium influx and the acrosome reaction in spermatozoa, but cannot be penetrated by sperm |
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| Authors: | Catherine Patrat Jana Auer Patricia Fauque Roger L Leandri Pierre Jouannet and Catherine Serres |
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| Institution: | (1) Biologie de la Reproduction, H?pital Cochin, AP-HP, Universit? Paris Descartes, Facult? de M?decine, Paris, France |
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| Abstract: | Background The functions of three zona glycoproteins, ZP1, ZP2 and ZP3 during the sperm-zona pellucida (ZP) interaction are now well
established in mice. The expression of an additional zona glycoprotein, ZPB/4, in humans, led us to reconsider the classical
mouse model of gamete interaction. We investigated the various functions of human ZP (hZP) during the interaction of spermatozoa
with fertilised and unfertilised oocytes. |
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