Alternative promoter usage of the membrane glycoprotein CD36 |
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| Authors: | Malin Andersen Boris Lenhard Carl Whatling Per Eriksson Jacob Odeberg |
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| Affiliation: | (1) Department of Biotechnology, AlbaNova University Center, Royal Institute of Technology (KTH), 106 91, Stockholm, Sweden;(2) Bergen Center for Computational Science, Computational Biology Unit, H?yteknologisenteret, Thorm?hlensgate 55, N-5008 Bergen, Norway;(3) Atherosclerosis Research Unit, King Gustaf V Research Institute, Karolinska Institutet, Stockholm, Sweden;(4) Department of Molecular Pharmacology, AstraZeneca R&D M?lndal, Molndal, Sweden |
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| Abstract: | Background CD36 is a membrane glycoprotein involved in a variety of cellular processes such as lipid transport, immune regulation, hemostasis, adhesion, angiogenesis and atherosclerosis. It is expressed in many tissues and cell types, with a tissue specific expression pattern that is a result of a complex regulation for which the molecular mechanisms are not yet fully understood. There are several alternative mRNA isoforms described for the gene. We have investigated the expression patterns of five alternative first exons of the CD36 gene in several human tissues and cell types, to better understand the molecular details behind its regulation. |
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