Preparation and biological activity of 5,6-dihydro-5-azapyrimidine nucleosides |
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| Authors: | A Pískala B Cesneková J Vesely |
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| Institution: | Institute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Sciences, Praha. |
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| Abstract: | The reaction of 5-azapyrimidine nucleosides Ia-IXa with zinc powder in acetic acid afforded the respective 5,6-dihydro derivatives Ib-IXb in high yields. This procedure represents a convenient and general method for preparation of the title compounds. The effects of some dihydro-5-azapyrimidine nucleosides on the growth in vitro of L1210 mouse leukemic cells were estimated. |
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