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Immunosuppressive diacetylenes, ceramides and cerebrosides from Hydrocotyle leucocephala |
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| Authors: | Ramos Freddy Takaishi Yoshihisa Kawazoe Kazuyoshi Osorio Coralia Duque Carmenza Acuña Ricardo Fujimoto Yoshinori Sato Mitsunobu Okamoto Masato Oshikawa Tetsuya Ahmed Sharif Uddin |
| Affiliation: | Pharmacognosy Laboratory, Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomashi 1-78, Tokushima 770-8505, Japan. |
| Abstract: | Three C-17 diacetylenic compounds (1-3), one monoterpenoid (4), seven ceramides (leucoceramides A-G, 5a-g), six cerebrosides (leucocerebrosides A-F, 6a-f) and nine known compounds were isolated from the methanolic extract of Hydrocotyle leucocephala. Their structures were established by spectroscopic methods. The isolated compounds 1-3, 5a-g, 6a-f and 7 were shown to be active in the lipopolysaccharide (LPS) induced cytokine production assay for IL-10, IL-12, and TNF-alpha. |
| Keywords: | Hydrocotyle leucocephala Apiaceae C-17 diacetylenes 4-hydroxy-4-(1-hydroxy-1-methylethyl)-cyclohex-2-en-1-one Leucoceramides Leucocerebrosides Cytokine production assay |
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