4-1BB cross-linking enhances the survival and cell cycle progression of CD4 T lymphocytes |
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Authors: | Lee Hyeon-Woo Nam Kyung-Ok Seo Su K Kim Young H Kang Hyun Kwon Byoung S |
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Institution: | The Immunomodulation Research Center and Graduate Program in Immunology and Biomedicine, University of Ulsan, Ulsan 680-749, Republic of Korea. hyeonwoo@mail.ulsan.ac.kr |
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Abstract: | 4-1BB, a T cell co-stimulatory receptor, prolongs the survival and multiplication of CD4 T cells. Cross-linking 4-1BB stimulated expression of the anti-apoptotic genes bcl-XL and bcl-2, as well as of cyclins D2 and E, and inhibited expression of the cyclin-dependent kinase (cdk) inhibitor p27kip1. Ova-activated CD4 T cells of 4-1BB-deficient/DO11.10 TCR transgenic mice survived less well and underwent less expansion than cells of wild type DO11.10 TCR transgenic mice. These findings demonstrate that 4-1BB is a co-stimulatory molecule for CD4 T cell survival and expansion in vivo. |
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Keywords: | 4-1BB CD4 T cells Cell cycle Survival bcl-XL bcl-2 Cyclins p27kip1 DO11 10 TCR transgenic mice |
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