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Perhydrolase-nanotube paint composites with sporicidal and antiviral activity |
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| Authors: | Navdeep Grover Marc P Douaisi Indrakant V Borkar Lillian Lee Cerasela Zoica Dinu Ravi S Kane Jonathan S Dordick |
| Institution: | 1. Department of Chemical and Biological Engineering, Rensselaer Nanotechnology Center, and Center for Biotechnology & Interdisciplinary Studies, Rensselaer Polytechnic Institute, Troy, NY, 12180, USA 2. Department of Chemical Engineering, Benjamin M. Statler College of Engineering and Mineral Resources, West Virginia University, Morgantown, WV, 26506, USA 3. Department of Chemical and Biological Engineering, Rensselaer Polytechnic Institute, 4105 Center for Biotechnology & Interdisciplinary Studies, 110 8th Street, Troy, NY, 12180, USA 4. Department of Chemical and Biological Engineering, Department of Biology, Rensselaer Polytechnic Institute, 2213 Center for Biotechnology & Interdisciplinary Studies, 110 8th Street, Troy, NY, 12180, USA |
| Abstract: | AcT (perhydrolase) containing paint composites were prepared leading to broad-spectrum decontamination. AcT was immobilized onto multi-walled carbon nanotubes (MWNTs) and then incorporated into latex-based paints to form catalytic coatings. These AcT-based paint composites showed a 6-log reduction in the viability of spores of Bacillus cereus and Bacillus anthracis (Sterne) within 60 min. The paint composites also showed >4-log reduction in the titer of influenza virus (X-31) within 10 min (initially challenged with 107 PFU/mL). AcT-based paint composites were also tested using various perhydrolase acyl donor substrates, including propylene glycol diacetate (PGD), glyceryl triacetate, and ethyl acetate, with PGD observed to be the best among the substrates tested for generation of peracetic acid and killing of bacillus spores. The operational stability of paint composites was also studied at different relative humidities and temperatures to simulate real-life operation. |
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