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Mechanisms of T-cell protection from death by IRX-2: a new immunotherapeutic |
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| Authors: | Malgorzata Czystowska Miroslaw J. Szczepanski Marta Szajnik Karen Quadrini Harvey Brandwein John W. Hadden Theresa L. Whiteside |
| Affiliation: | (1) Research Pavilion at the Hillman Cancer Center, University of Pittsburgh Cancer Institute, 5117 Centre Avenue, Suite 1.27, Pittsburgh, PA 15213-1863, USA;(2) IRX Therapeutics, Inc, 1 Bioscience Park Drive, Farmingdale, NY 11735, USA; |
| Abstract: | ObjectivesIRX-2 is a novel immunotherapeutic containing physiologic quantities of several cytokines which protects human T lymphocytes from tumor-induced or drug-induced apoptosis. Here, we investigate the mechanisms responsible for IRX-2-mediated protection of T lymphocytes exposed to tumor-derived microvesicles (TMV). |
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