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Molecular analysis of melanoma-induced sentinel lymph node immune dysfunction |
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| Authors: | Jonathan H. Lee Yun Chen Joseph L. Chan You-wen Qian James S. Goydos |
| Affiliation: | (1) Department of Surgery/Division of Surgical Oncology, CINJ/UMDNJ/RWJ Medical School, The Cancer Institute of New Jersey, 195 Little Albany Street, Room 3000, New Brunswick, NJ 08901, USA;(2) Department of Pathology and Laboratory Medicine, UMDNJ/RWJ Medical School, 1 Robert Wood Johnson Place, New Brunswick, NJ 08901-1966, USA |
| Abstract: | IntroductionSentinel lymph nodes (SLNs) of melanoma patients show evidence of tumor-induced immune dysfunction. Our previous works have shown that IL-10 and IFNγ co-regulate indoleamine-2,3-dioxygenase (IDO)-expressing immunosuppressive dendritic cells (DCs) in melanoma SLNs. The goal of this study is to examine the relationship between melanoma SLN tumor burden and the degree of SLN immune dysfunction as a model to study tumor-induced immune dysfunction. We hypothesize that SLN tumor burden correlates with the degree of SLN immune dysfunction. |
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