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Difluoromethyl analogs of the natural hormone 1α,25-dihydroxyvitamin D3: Design, synthesis, and preliminary biological evaluation |
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| Authors: | Gary H Posner Byung Chul Suh Kimberly S Petersen Patrick Dolan Elin S Agoston Thomas W Kensler John T Koh Sara Peleg |
| Institution: | aDepartment of Chemistry, The Johns Hopkins University, Baltimore, MD 21218, USA;bDivision of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD 21205, USA;cDepartment of Chemistry and Biochemistry, The University of Delaware, Newark, DE 19716, USA;dDepartment of Medical Specialties, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA |
| Abstract: | |
| Keywords: | Fluorinated D analogs Growth inhibition Low-calcemic Protease digestion assay VDR binding |
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