Immunohistochemical analysis of inflammatory infiltrates around the injection site of a streptococcal preparation,OK-432, in rat tongue |
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| Authors: | Atsushi Niimi Tetsuroh Shinoda Toshio Kaneda Hiroshi Nagura |
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| Institution: | (1) Department of Oral Surgery, Nagoya University, School of Medicine, 65 Tsuruma-cho, 466 Showa-ku, Nagoya, Japan;(2) Department of Pathology, Tohoku University, School of Medicine, 2-1 Seiryomachi, 980 Aoba-ku, Sendai, Japan |
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| Abstract: | On the assumption that neutrophils around the injection site of OK-432, a heat- and penicillin-treated lyophilized preparation of the Su strain ofStreptococcus pyogenes, enhance immunologic response through the production of Interleukin-1 (IL-1), OK-432 was injected into rat tongue, and specimens from the tongue were immunohistochemically investigated at various intervals after the injection, to clarify the process of inflammatory and immune responses at the injection site. Neutrophils and mononuclear cells appeared around the OK-432 injection site after 1 hour, increased to their maximum level at 24 hours, and then decreased from the 3rd to the 7th day. IL-1 was detected on neutrophils 3 hours after the injection, and OX-08-positive cells (suppressor/cytotoxic T cells and the majority of natural killer cells) remarkably increased. OX-39-positive cells (IL-2 receptor) appeared after 12 hours. These results suggest that neutrophils around the injection site of OK-432 at early phases of inflammation play a role in the expression of BRM function through IL-1. |
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| Keywords: | biological response modifier immunohistochemistry interleukin 1 neutrophil |
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