Mutagenicities of N-nitrosamines on Salmonella. |
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Authors: | T Yahagi M Nagao Y Seino T Matsushima T Sugimura |
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Affiliation: | 1. Biochemistry Division, National Cancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo, Japan;2. Tokyo Biochemical Research Institute, Takada, Toshima-ku, Tokyo, Japan |
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Abstract: | The mutagenic activities of 11 N-nitrosamines were tested using Salmonella typhimurium TA100 and TA98. All the carcinogenic N-nitrosamines were mutagenic on TA100 with a drug-activating system from the rat liver, whereas N,N-diphenylnitrosamine, a non-carcinogen, was not mutagenic. None of the N-nitrosamines was mutagenic on TA98, except N,N-diethylnitrosamine which was weakly mutagenic. To detect the mutagenicity of N,N-dimethylnitrosamine, the pre-incubation of bacteria and N,N-dimethylnitrosamine with S-9 Mix before if was poured onto plates was obligatorily required. Dimethyl sulfoxide inhibited the mutagenic effect of N,N-dimethylnitrosamine. |
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Keywords: | DMN DEN DBN DAN MBN PBN BAN MDN MBeN DPhN DMSO dimethyl sulfoxide PB sodium phenobarbital PCB polychlorinated biphenyl (KC-500) G6P glucose-6-phosphate G6PD glucose-6-phosphate dehydrogenase |
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