shape In vitro effects of diacetoxyscirpenol (DAS) on human and rat granulo-monocytic progenitors |
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Authors: | Lautraite Sophie Rio Bénédicte Guinard Jocelyne Parent-Massin Dominique |
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Affiliation: | 1.Laboratoire de Microbiologie et de Sécurité Alimentaire, Ecole Supérieure de Microbiologie et Sécurité Alimentaire de Brest, ISAMOR, Technop?le Brest-Iroise, 29280, Plouzané, France ; |
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Abstract: | Diacetoxyscirpenol (DAS) is a trichothecene mycotoxin produced by various species of fungi. Trichothecenes are known as major contaminants of cereals and cereal-containing foods. DAS has been detected in agricultural products worldwide and persists in products after processing. In human as well as in animals, DAS consumption has been shown to induce haematological disorders (neutropenia, aplastic anemia). Granulo-monocytic progenitors (CFU-GM) from human umbilical cord blood and rat bone marrow have been cultured in the presence of DAS (from 10-8 M to 5 × 10-10 M) for 14 days. Study of concentration and effect relationships have shown a sharp effect of DAS on rat CFU-GM between 10-7 M and 10-8 M, while human CFU-GM are able to grow in the presence of 10-8 M of the toxin. IC50 values on day 14 are respectively, 7.6 × 10-9 M for human CFU-GM and 6.2 × 10-9 M for rat CFU-GM. This revised version was published online in June 2006 with corrections to the Cover Date. |
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Keywords: | diacetoxyscirpenol (DAS) food toxicology haematotoxicity human CFU-GM rat CFU-GM trichothecene mycotoxin |
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