Helicobacter and Gastric Malignancies |
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| Authors: | António Carlos Ferreira Hajime Isomoto Masatsugu Moriyama Toshio Fujioka José Carlos Machado Yoshio Yamaoka |
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| Institution: | IPATIMUP –Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal,;Faculty of Medicine, University of Porto, Porto, Portugal,;Department of Endoscopy, Nagasaki University School of Medicine, Nagasaki, Japan,;Department of Molecular Pathology, Oita University, Yufu City, Oita 879-5593, Japan,;Department of Gastroenterology, Faculty of Medicine, Oita University, Yufu City, Oita 879-5593, Japan,;Department of Medicine-Gastroenterology, Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine, Houston, Texas 77030, USA |
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| Abstract: | Individuals infected with Helicobacter pylori , a stomach colonizing bacteria, have an increased risk of developing gastric malignancies. The risk for developing cancer relates to the physiologic and histologic changes that H. pylori infection induces in the stomach. In the last year numerous studies have been conducted in order to characterize the association between H. pylori infection and gastric cancer. These studies range from epidemiologic approaches aiming at the identification of environmental, host genetic, and bacterial factors associated with risk of gastric cancer, to molecular and cell biology approaches aiming at understanding the interaction between H. pylori and the transforming epithelial cell. In this review an account of the last year's research activity on the relationship between H. pylori and gastric cancer will be given. |
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| Keywords: | Helicobacter pylori gastric cancer MALT lymphoma |
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