Cis-dominant regulatory mutations affecting the expression of GABA permease in Aspergllus nidulans |
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| Authors: | Christopher R Bailey Hugh A Penfold and Herbert N Arst Jr |
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| Institution: | (1) Present address: Department of Genetics, University of Cambridge, Downing Street, CB2 3EH Cambridge, England;(2) Present address: Beecham Pharmaceuticals, Clarendon Road, BN14 8QH Worthing, West Sussex, England;(3) Present address: Département de Microbiologie, Centre Hospitalier Universitaire, Université de Sherbrooke, JIH 5N4 Sherbrooke, P.Q., Canada |
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| Abstract: | Summary In Aspergillus nidulans expression of the gabA gene, the probable structural gene for the  -amino-n-butyrate (GABA) permease, is controlled by induction, via the intA gene, ammonium repression, mediated by the areA gene, and probably carbon catabolite repression. Regulatory mutations, tightly linked to gabA, were selected by reverting an areA-2 strain on GABA as nitrogen source. These mutations, gabI-1, gabI-2, and gabI-3 result in increased gabA expression and are cis-dominant in their effects on the gabA gene. Mapping data show that the regulatory mutations map on one side of all gabA- alleles tested. |
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