Retinoic acid induces transforming growth factor-beta 2 in cultured keratinocytes and mouse epidermis. |
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| Authors: | A B Glick K C Flanders D Danielpour S H Yuspa M B Sporn |
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| Affiliation: | Laboratory of Chemoprevention, National Cancer Institute, Bethesda, Maryland 20892. |
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| Abstract: | We have studied the functional interaction between retinoic acid and transforming growth factor-beta (TGF-beta), using the mouse epidermis as a model system. Treatment with retinoic acid increases expression of TGF-beta 2 in cultured keratinocytes in vitro, as well as in the epidermis in vivo. This TGF-beta 2 is secreted in a biologically active form that can bind to surface receptors, in contrast to most other conditions in which TGF-beta is secreted in a latent form. Specific antibodies to TGF-beta 2 partially reverse the ability of retinoic acid to inhibit DNA synthesis in cultured keratinocytes. The regulation of TGF-beta 2 expression by retinoic acid may have important physiological and pharmacological roles in the maintenance of epidermal homeostasis. |
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