Gastrulation in the mouse: the role of the homeobox gene goosecoid. |
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Authors: | M Blum S J Gaunt K W Cho H Steinbeisser B Blumberg D Bittner E M De Robertis |
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Affiliation: | Molecular Biology Institute, University of California, Los Angeles 90024-1737. |
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Abstract: | Mouse goosecoid is a homeobox gene expressed briefly during early gastrulation. Its mRNA accumulates as a patch on the side of the epiblast at the site where the primitive streak is first formed. goosecoid-expressing cells are then found at the anterior end of the developing primitive streak, and finally in the anteriormost mesoderm at the tip of the early mouse gastrula, a region that gives rise to the head process. Treatment of early mouse embryos with activin results in goosecoid mRNA accumulation in the entire epiblast, suggesting that a localized signal induces goosecoid expression during development. Transplantation experiments indicate that the tip of the murine early gastrula is the equivalent of the organizer of the amphibian gastrula. |
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