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Enantiospecific analysis of ketoprofen in plasma by high-performance liquid chromatography |
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| Authors: | PJ Hayball RL Nation F Bochner RK Le Leu |
| Institution: | Pharmacy Department, Repatriation General Hospital, Daw Park, SA 5041 Australia Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5000 Australia School of Pharmacy, University of South Australia, Adelaide, SA 5000 Australia Department of Clinical and Experimental Pharmacology, University of Adelaide, Adelaide, SA 5000 Australia Pharmacy Department, Repatriation General Hospital, Daw Park, SA 5041 Australia |
| Abstract: | A high-performance liquid chromatographic (HPLC) assay for the determination of the R- and S-enantiomers of ketoprofen is described. Facile ketoprofen extraction from plasma and derivatization to the diastereomeric S-1-phenylethylamides was followed by normal-phase HPLC. The ketoprofen diastereomeric amides eluted within 8 min. The limit of quantification of the assay was 0.15 mg/l of each enantiomer (signal-to-noise RATIO = 5). |
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