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Klf15 orchestrates circadian nitrogen homeostasis
Authors:Jeyaraj Darwin  Scheer Frank A J L  Ripperger Jürgen A  Haldar Saptarsi M  Lu Yuan  Prosdocimo Domenick A  Eapen Sam J  Eapen Betty L  Cui Yingjie  Mahabeleshwar Ganapathi H  Lee Hyoung-gon  Smith Mark A  Casadesus Gemma  Mintz Eric M  Sun Haipeng  Wang Yibin  Ramsey Kathryn M  Bass Joseph  Shea Steven A  Albrecht Urs  Jain Mukesh K
Institution:Case Cardiovascular Research Institute, Harrington Heart and Vascular Institute, Department of Medicine, Western Reserve University, Cleveland, OH 44106, USA.
Abstract:
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  • Highlights? Nitrogen homeostasis exhibits circadian rhythmicity in mammals ? Klf 15 regulates rhythmic amino acid utilization and ammonia detoxification ? Krüppel-like factor 15 is regulated by the circadian clock ? Feeding is a major external cue regulating Klf15 rhythmicity and nitrogen homeostasis
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