| 逆转肾小管上皮细胞转分化的Smad信号转导机制 |
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| 引用本文： | 郝艳鹏,张悦.逆转肾小管上皮细胞转分化的Smad信号转导机制[J].生命科学,2010(2):169-172. |
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| 作者姓名： | 郝艳鹏 张悦 |
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| 作者单位： | 上海中医药大学科技实验中心; |
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| 基金项目： | 国家自然科学基金项目(30371834); 上海市教育委员会重点学科(第五期)(J50301) |
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| 摘 要： | 肾小管上皮细胞转分化(tubular epithelial to menchymal transdifferentiation,EMT)是肾小管间质纤维化的重要病理机制之一。致纤维化细胞因子TGF-β通过几种信号转导途径调节EMT,其中TGF-β/Smads信号通路发挥核心作用。目前研究表明,Smad7、HGF、BMP-7等可通过调控Smads信号通路而逆转EMT,这为肾间质纤维化的防治提供了新的思路。该文主要介绍TGF-β/Smads信号通路在EMT发生的作用,以及Smad7、SnoN、HGF、BMP-7等分子是如何通过抑制Smads信号通路而发挥逆转EMT作用的。
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| 关 键 词： | 肾小管上皮细胞 转分化 逆转 信号转导 |
The mechanisms of reversing tubular epithelial myofibroblast transdifferentiation by Smad signal transduction |
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| HAO Yan-peng,ZHANG Yue.The mechanisms of reversing tubular epithelial myofibroblast transdifferentiation by Smad signal transduction[J].Chinese Bulletin of Life Sciences,2010(2):169-172. |
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| Authors: | HAO Yan-peng ZHANG Yue |
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| Institution: | HAO Yan-peng,ZHANG Yue(Experiment Center for Science , Technology,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China) |
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| Abstract: | Tubular epithelial myofibroblast transdifferentiation（EMT） is an important pathomechanism of renal tubulointerstitial fibrosis.Transforming growth factor-β（TGF-β） is the most potent inducer that is capable of initiating and completing the entire EMT course by several signal transduction pathway,among which,TGF-β Smads is the most important one.Studies indicated that Smad7,SnoN,HGF,BMP-7 could reverse EMT by regulating Smads signal pathway,which represents a potential therapeutic approach to renal tubulointerstitial fibrosis.This review tries to interpret the role of TGF-β Smads signal pathway in EMT and the way through which Smad7、SnoN、HGF and BMP-7 reverse EMT by inhibiting Smads signal pathway. |
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| Keywords: | renal tubular epithelial cell transdiferentiation reverse signal transduction |
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