Marker-assisted selection in autogamous RIL populations: a simulation study |
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Authors: | R van Berloo Piet Stam |
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Institution: | (1) C.T. de Wit Graduate school of Production Ecology, Department of Plant Breeding, Wageningen Agricultural University, PO box 386, Wageningen, The Netherlands Fax: +31 317 483457 E-mail: ralph.vanberloo@users.pv.wau.nl, NL |
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Abstract: | Molecular markers may enable plant breeders to select indirectly for genes affecting quantitative traits by selecting for
molecular markers closely linked to these genes (marker-assisted selection, MAS). We have assessed the effectiveness of MAS
compared to phenotypic selection. Key variables in this assessment were: trait heritability, selection intensity, genetic
architecture and uncertainty in QTL mapping. Simulation studies showed that the application of MAS in autogamous crops, with
the objective of obtaining transgressive genotypes, can improve selection results when compared to conventional selection
procedures. Marker-assisted selection appears particularly promising when dominant alleles at quantitative trait loci are
present and linked in coupling phase. Uncertainty in estimated QTL map positions reduces the benefits of marker-assisted selection,
but this reduction remains limited in most cases.
Received: 5 September 1997 / Accepted: 6 October 1997 |
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Keywords: | Marker-assisted selection Simulation Quantitative trait loci Complementation |
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