Synthesis and antibacterial activity of 6-O-arylpropargyl-9-oxime-11,12-carbamate ketolides |
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| Authors: | Beebe Xenia Yang Fan Bui Mai H Mitten Michael J Ma Zhenkun Nilius Angela M Djuric Stevan W |
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| Affiliation: | Infectious Disease Research, Abbott Laboratories, Abbott Park, IL 60064, USA. xenia.b.searle@abbott.com |
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| Abstract: | A series of novel 6-O-arylpropargyl-9-oxime-ketolides was synthesized and evaluated against various pathogens. These new compounds show promising in vitro antibacterial potency and in vivo efficacy against macrolide resistant strains. |
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