Polyamines control the growth of the fish-killing dinoflagellate Karenia mikimotoi in culture |
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| Institution: | 1. Dalton Cardiovascular Research Center, University of Missouri-Columbia, Columbia, MO 65211, USA;2. Molecular Genetics Department, Instituto de Fisiología Celular, UNAM, Mexico City, Mexico;1. IRTA, Ctra. Poble Nou km 5.5, 43540 Sant Carles de la Ràpita, Tarragona, Spain;2. Department of Fibre and Polymer Technology, KTH Royal Institute of Technology, Teknikringen 56, 10044 Stockholm, Sweden;3. Departament d''Enginyeria Química, Universitat Rovira i Virgili, Av. Països Catalans 26, 43007 Tarragona, Spain;4. Institució Catalana de Recerca i Estudis Avançats (ICREA), Pg. Lluís Companys 23, 08010 Barcelona, Spain;1. Department of Biotechnology, Lahore College for Women University, Lahore, Pakistan |
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| Abstract: | Effects of intracellular polyamines on the growth of the harmful dinoflagellate Karenia mikimotoi were investigated in culture experiments using an axenic culture. Polyamines were analyzed with HPLC. Free norspermine was the most abundant polyamine during growth of K. mikimotoi. Cellular norspermidine contents increased significantly during the exponential growth phase with increasing growth rate. The maximum growth yield of K. mikimotoi was reduced by the polyamine biosynthetic inhibitor, d,l-alpha-difluoromethylornithine (DFMO) which inhibits ornithine decarboxylase. These results suggest that polyamines, especially free norspermine, play significant roles in the growth of K. mikimotoi. |
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| Keywords: | Norspermine Polyamine |
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