Interleukin-18 gene polymorphism,but not interleukin-2 gene polymorphism,is associated with rheumatoid arthritis |
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| Authors: | Cheng-Chun Lee Wei-Yong Lin Lei Wan Yuhsin Tsai Ying-Ju Lin Chang-Hai Tsai Chung-Ming Huang Fuu-Jen Tsai |
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| Affiliation: | (1) Department of Medical Research, China Medical University Hospital, No. 2 Yuh Der Road, Taichung, Taiwan;(2) Graduate Institute of Integrated Medicine, China Medical University, Taichung, Taiwan;(3) Graduate Institute of Chinese Medical Science, China Medical University, Taichung, Taiwan;(4) Department of Biotechnology and Bioinformatics, Asia University, Taichung, Taiwan;(5) Graduate Institute of Acupuncture Science, China Medical University, Taichung, Taiwan;(6) Division of Immunology and Rheumatology, China Medical University Hospital, Taichung, Taiwan |
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| Abstract: | To investigate whether polymorphisms of IL-2 and IL-18 genes are associated with rheumatoid arthritis (RA), polymorphisms of IL-2 and IL-18 genes were detected by polymerase-chain-reaction-based restriction analysis in the patients with RA and normal controls. The results for the IL-18 gene revealed a significant difference between the patients and the normal controls (p = 0.000003), but there was no significant difference for the IL-2 gene (p = 0.876). The IL-18 gene 105A allele was associated with RA in Chinese patients. Individuals possessing the 105A allele had a higher incidence of RA. A lack of association of IL-2 gene polymorphism between RA patients and healthy individuals was noted. The results of this study provide genetic evidence that IL-18-105A/C polymorphism may play an effective role in RA. |
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| Keywords: | Rheumatoid arthritis Interleukin-18 (IL-18) Interleukin-2 (IL-2) Single nucleotide polymorphisms (SNPs) |
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