Effect of phorbol myristate acetate on processing of formyl peptide receptors by human neutrophils |
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| Authors: | E Lobo F Elfman E Kelly H D Perez |
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| Institution: | Rosalind Russell Arthritis Research Laboratories, University of California, San Francisco. |
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| Abstract: | We examined the effect of phorbol myristate acetate on the ability of human neutrophils to process formyl peptide receptors. The receptor was affinity-labeled and its extracellular localization assessed over time, by cleavage of extracellular labeled receptor with papain. Neutrophils were capable of internalizing (and/or recycling) affinity labeled formyl peptide receptor in the absence of extracellular calcium. This phenomenon was dependent upon stimulation with phorbol myristate acetate, suggesting a role for protein kinase C in this process. |
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