Letter: Conformation of thyrotropin-releasing hormone: prediction from molecular orbital theory期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Letter: Conformation of thyrotropin-releasing hormone: prediction from molecular orbital theory

Authors:	J M George L B Kier

Institution:	Department of Medicine, Ohio State University, Columbus, Ohio 43210, U.S.A.;Department of Chemistry, Massachusetts College of Pharmacy, Boston, Massachusetts 02115, U.S.A.

Abstract:	The extended Huckel molecular orbital method was used to predict the preferred conformation of thyrotropin releasing hormone (TRH). Calculation of the whole molecule confirmed the conformational preferences of the individual amino acid residues calculated separately. A stereochemical basis is predicted for the differing activity of $N^{1}^{im}$ methyl and $N^{3}^{im}$ methyl TRH analogues.

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