西安地区妊娠妇女不同孕期血清铁蛋白、叶酸和维生素B_(12)的水平及临床意义

目的:探讨西安地区妊娠妇女不同孕期血清铁蛋白、叶酸和维生素B12的水平及临床意义。方法:收集2012年8月至2013年1月在本院进行产前检查的750例妊娠期妇女及86例健康非妊娠妇女的血清标本。采用全自动化学发光免疫分析法测定其血清铁蛋白、叶酸和维生素B12的含量。结果:孕妇血清铁蛋白、叶酸和维生素B12的含量随孕期的增长而逐渐降低。早、中、晚孕期妇女叶酸的含量较对照组相比,并无显著差异(P0.05)。中、晚孕期妇女血清铁蛋白和维生素B12含量均显著低于对照组,差异有统计学意义(P0.05)。结论:西安地区中、晚孕期的孕妇体内存在铁蛋白和维生素B12缺乏,但并不缺乏叶酸。在重视补充叶酸的同时,也应该重视对铁和维生素B12的补充。

Serum levels and Clinical Significance of the Ferritin, Folic Acid and VitaminB12in the Pregnant Women at Different Gestational stages in Xi'an

ABSTRACT Objective:To investigate the serum levels and clinical significance of the ferritin, folic acid and VitaminB12in thepregnant women at different gestational stages in Xi''An.Methods: Fully automated chemiluminescence immunoassay was used to detectthe serum ferritin, folic acid and VitB12levels in 750 pregnant wemen and 86 normal wemen who was admitted in our hospital from August 2012 to January 2013. Results:The serum ferritin, folic acid and VitB12contents of pregnant women were decreased with the extension of gestational weeks. No significant difference was found in the serum folic acid content among pregnant women at early, mid-term,late pregnancy as well as the normal control group (P>0.05). But the serum ferritin and VitB12 contents of pregnant women at mid-term,late pregnancy were both significantly lower than that of the normal control group (P<0.05).Conclusion: The lack of ferritin and VitB12was found in the pregnant women at mid-term, late pregnancy, while folic acid wasn''t deficient. The supplement of ferritin and VitB12should be attached the same importance as folic acid.