Metabolism and action of the prostaglandin endoperoxide PGH2 in rat kidney |
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Authors: | T V Zenser C A Herman R R Gorman B B Davis |
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Institution: | 1. Geriatric Center, V.A. Hospital, St. Louis University Medical School, St. Louis, Mo. 63125 USA;2. Experimental Biology Research, The Upjohn Company, Kalamazoo, Mich., USA |
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Abstract: | Kidney membrane fractions metabolized 1-14C]PGH2 to TXB2, PGE2, PGF2α, PGD2, 6-keto PGF1α, and HHT. TXA2, as measured by TXB2, was enzymatically formed in cortex microsomes and was identified by thin layer chromatography and gas chromatography - mass spectrometry. PGH2 caused a labile inhibition of cortical PGE2-stimulated adenylate cyclase. PGE2, PGF2α, and PGD2 are stimulators of cortical adenylate cyclase. The inability of two thromboxane synthetase inhibitors, imidazole and 9,11-azoprosta-5,13 dienoic acid, to block PGH2 inhibition suggested that TXA2 was not an obligatory intermediate in this process. Therefore, a potential function of cortical PGH2 is inhibition of adenylate cyclase. |
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