| 糖基磷脂酰肌醇锚定蛋白质与肿瘤血管生成的关系 |
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| 引用本文： | 朱旭锦,唐建华. 糖基磷脂酰肌醇锚定蛋白质与肿瘤血管生成的关系[J]. 生命的化学, 2010, 0(1) |
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| 作者姓名： | 朱旭锦 唐建华 |
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| 作者单位： | 中南大学生物科学与技术学院生物化学系; |
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| 基金项目： | 国家自然科学基金(39970315,30271456)资助 |
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| 摘 要： | 肿瘤血管生成是一个非常复杂的过程,涉及到多种因子的调节。目前,已发现多种糖基磷脂酰肌醇锚定蛋白质与肿瘤血管生成密切相关。尿激酶型纤溶酶原激活剂受体(urokinase plasminogen activator receptor,uPAR/CD87)、CD55、基质金属蛋白酶、T-钙黏着蛋白、RECK、Eph家族受体作用蛋白A(Eph family receptor interacting protein A,ephrin A)等均能调节肿瘤血管生成过程。本文对糖基磷脂酰肌醇锚定的调节因子如何影响肿瘤血管生成,以及它们作为肿瘤治疗的主要靶标研究进行综述,为肿瘤治疗的抗血管生成新靶标的设计提供信息。
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| 关 键 词： | 血管生成 糖基磷脂酰肌醇锚定蛋白 肿瘤治疗 |
Glycosylphosphatidylinositol-anchored protein and tumor angiogenesis |
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| Xu-Jin Zhu,Jian-Hua Tang. Glycosylphosphatidylinositol-anchored protein and tumor angiogenesis[J]. Chemistry of Life, 2010, 0(1) |
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| Authors: | Xu-Jin Zhu Jian-Hua Tang |
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| Affiliation: | Xu-Jin Zhu,Jian-Hua Tang Department of Biochemistry,School of Biological Sciences , Technology,Central South University,Changsha 410078,China |
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| Abstract: | Angiogenesis is a very complicated process regulated by many kinds of factors.Presently,it has been found that occurrence of angiogenesis were closely correlated with glycosylphosphatidylinositol-anchored proteins,including CD87,CD55,MMP,T-cadherin,RECK,and ephrinsa A.This article summarizes the GPI-anchored regulated factors affecting tumor angiogenesis and current targets of anti-angiogenesis for tumor therapy,which will provide information for designing new antiangiogenesis targets used in tumor therapy. |
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| Keywords: | glycosylphosphatidylinositol-anchored protein angiogenesis tumor therapy |
| 本文献已被 CNKI 等数据库收录！ |
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