| 瘦素与软骨代谢 |
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| 引用本文： | 郭震,姚勐炜,吴旭,涂意辉,蒋雷生.瘦素与软骨代谢[J].现代生物医学进展,2013,13(14):2777-2779. |
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| 作者姓名： | 郭震 姚勐炜 吴旭 涂意辉 蒋雷生 |
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| 作者单位： | 1. 上海同济大学附属杨浦医院骨科 上海200090
2. 上海交通大学附属新华医院骨科 上海200090 |
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| 摘 要： | 瘦素最初发现是在白色脂肪组织产生并且与脂肪组织量有强相关性的激素物质。它最初发现于1994年,并且在中枢神经系统起到限制食物摄入,刺激能量消耗的作用。目前发现在几乎所有的组织内都有瘦素受体的表达,而且在细胞层面瘦素参与各种各样的生物学功能,包括免疫反应、炎性疾病以及心血管、呼吸系统的病理生理过程。目前大量研究表明,瘦素在软骨代谢也发挥了重要作用,现综述如下。
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| 关 键 词： | 瘦素 软骨代谢 综述 |
Leptin and Cartilage Metabolism |
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| GUO Zhen,YAO Meng-wei,WU Xu,TU Yi-hui,JIANG Lei-sheng.Leptin and Cartilage Metabolism[J].Progress in Modern Biomedicine,2013,13(14):2777-2779. |
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| Authors: | GUO Zhen YAO Meng-wei WU Xu TU Yi-hui JIANG Lei-sheng |
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| Institution: | 1 Department of Orthopedics,Yangpu Hospital,affiliated to Tongji University,Shanghai,200090,China; 2 Department of Orthopedics,Xinhua Hospital,affiliated to Shanghai Jiaotong University,Shanghai,200090,China) |
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| Abstract: | Leptin is a hormone that was initially found to be synthesized by white adipocytes and has a strong correlation with the amount of adipose tissue.Leptin was first discovered in 1994 and found to act as a signal for the central nervous system to inhibit food intake and to stimulate energy expenditure.More recent findings on the ubiquitous expression of leptin receptors in almost all tissues and on its cellular effects have revealed that leptin is also involved in the regulation of a variety of biological functions related to immune responses and inflammatory diseases,and to cardiovascular and respiratory pathophysiology.More and more studies show that：Leptin also plays an important role in the cartilage metabolism,and now we review as follows. |
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| Keywords: | Leptin Cartilage metabolism Review |
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