Synergistic inhibition of carboxypeptidase A by zinc ion and imidazole |
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Authors: | Mock W L Wang L |
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Institution: | Department of Chemistry, University of Illinois at Chicago, Chicago, Illinois 60607-7061, USA. wlmock@uic.edu |
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Abstract: | Zinc ion in solution yields a 560-fold enhancement in the kinetic inhibition of carboxypeptidase A by the simple heterocycle imidazole, behavior attributed to formation of a ternary complex of the three species. However, the effect is partially negated by formation of less-inhibitory Zn2+(C3H4N2)2-4 coordination complexes, providing for the enzyme an anomalous profile of catalytic rate versus imidazole concentration. |
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