Alterations in serum and brain trace element levels after antidepressant treatment |
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Authors: | Gabriel Nowak Ma?gorzata Schlegel-Zawadzka |
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Institution: | (1) Department of Pharmacology, Institute of Pharmacology, Polish Academy of Sciences, Smetna 12, 31-343 Kraków, Poland;(2) Department of Food Chemistry and Nutrition, Collegium Medicum, Jagiellonian University, Medyczna 9, 30-688 Kraków, Poland |
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Abstract: | We have studied the effect of chronic treatment with imipramine, citalopram and electroconvulsive shock (ECS) on serum and
brain zinc levels in rats. Chronic treatment with citalopram (but not with imipramine or ECS) significantly (approx 20%) increased
the serum zinc level. Chronic treatment with both drugs slightly (by approx 10%) increase the zinc level in the hippocampus
and slightly decreased it in the cortex, cerebellum and basal forebrain. Calculation of the ratio hippocampus/brain region
within each group demonstrated a significantly (approx 20%) higher value after treatment with either imipramine or citalopram.
Moreover, chronic ECS induced a significant increase (by 30%) in the zinc level in the hippocampus and also a slight increase
(by 11–15%) in the other brain regions. Thus, these different antidepressant therapies induced an elevation of the hippocampal
zinc concentration, which indicates a significant role of zinc in the mechanism of antidepressant therapy. |
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Keywords: | Antidepressant drugs ECS zinc level brain serum rats |
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