Assignment of a gene for human quinoid-dihydropteridine reductase (QDPR,EC 1.6.5.1) to chromosome 4 |
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| Authors: | P Kuhl K Olek P Wardenbach K -H Grzeschik |
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| Institution: | (1) Institut für Humangenetik der Universität Bonn, Wilhelmstraße 31, D-5300 Bonn, Federal Republic of Germany;(2) Institut für Humangenetik der Universität Münster, Vesaliusweg 12-14, D-4400 Münster, Federal Republic of Germany |
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| Abstract: | Summary An acrylamide gel electrophoretic procedure is described which allows the separation of human quinoid-dihydropteridine reductase (QDPR), EC 1.6.5.1) from the homologous enzyme expressed in established rodent cell lines. The human enzyme marker segregates exclusively with chromosome 4 in a series of well characterized man-mouse somatic cell hybrid clones from our clone bank. This observation supports the assignment of a structural gene for QDPR to human chromosome 4. |
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