Active hexose correlated compound enhances tumor surveillance through regulating both innate and adaptive immune responses |
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Authors: | Yunfei Gao Dongqing Zhang Buxiang Sun Hajime Fujii Ken-Ichi Kosuna Zhinan Yin |
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Institution: | (1) Section of Rheumatology, Department of Medicine, Yale School of Medicine, CAB Building, Room 517, 300 Cedar Street, 208031, New Haven, CT 06520-8031, USA;(2) Shanghai Institute of Immunology, Shanhai Jiaotong University School of Medicine, 004-0839 Shanhai, China;(3) R&D Division, Amino Up Chemical Co., Ltd, 004-0839 Sapporo, Japan |
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Abstract: | Active hexose correlated compound (AHCC) is a mixture of polysaccharides, amino acids, lipids and minerals derived from cocultured mycelia of several species of Basidiomycete mushrooms. AHCC has been implicated to modulate immune functions and plays a protective role against infection. However, the potential role of AHCC in tumor immune surveillance is unknown. In this study, C57BL/6 mice were orally administered AHCC or water, followed by tumor cell inoculation. We showed that compared to pure water-treated mice, AHCC treatment significantly delayed tumor development after inoculation of either melanoma cell line B16F0 or lymphoma cell line EL4. Treatment with AHCC enhanced both Ag-specific activation and proliferation of CD4+ and CD8+ T cells, increased the number of tumor Ag-specific CD8+ T cells, and more importantly, increased the frequency of tumor Ag-specific IFN-γ producing CD8+ T cells. Interestingly, AHCC treatment also showed increased cell number of NK and γδ T cells, indicating the role of AHCC in activating these innate-like lymphocytes. In summary, our results demonstrate that AHCC can enhance tumor immune surveillance through regulating both innate and adaptive immune responses. |
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Keywords: | Nutrition food T cells Tumor immunity IFN-γ Tumor therapy |
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