Harmful singlet oxygen can be helpful |
| |
Authors: | Hultén L M Holmström M Soussi B |
| |
Institution: | Wallenberg Laboratory for Cardiovascular Research, University of G?teborg, Sahlgrenska University Hospital, Sweden. |
| |
Abstract: | Highly reactive harmful singlet oxygen O2(1delta(g)) can be helpful while relaxing to its triplet ground state O2(3sigma(g)-). The energy emitted during this relaxation from the excited energy state is discernable at 634 nm. We report here on the effect of this energy as photon illumination and as energy transfer in air on the production of reactive oxygen species (ROS) by human monocytes, measured as isoluminol-enhanced chemiluminescence. We demonstrate up to 60% decrease in the secretion of ROS after 2-min illumination of the monocytes stimulated with phorbol myristate acetate (PMA). The results provide in vitro documentation of the utility of singlet oxygen energy in modifying cellular behaviour. |
| |
Keywords: | Human monocytes Singlet oxygen Reactive oxygen species Chemiluminescence Oxidative stress Photodynamic therapy Free radicals |
本文献已被 ScienceDirect PubMed 等数据库收录! |