The C-terminal 26-residue peptide of serpin A1 is an inhibitor of HIV-1 |
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Authors: | Congote Luis Fernando |
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Affiliation: | Department of Molecular Microbiology and Immunology, Division of Endothelial Cell Biology, Nagasaki, Japan. skanda-jua@umin.net |
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Abstract: | The signal transduction pathway involved in hepatocyte growth factor (HGF)-induced capillary morphogenesis of endothelial cells was investigated. HGF-induced capillary morphogenesis of the murine spleen endothelial cell line MSS31 was inhibited by a Src family kinase inhibitor, PP2. Stable expression of kinase-inactive Src in MSS31 cells inhibited HGF-induced activation of Src as well as capillary morphogenesis. The HGF-induced capillary morphogenesis of human umbilical vein endothelial cells was also inhibited by PP2 and was reduced by the downregulation of Src by small interfering RNA. These results suggest that HGF induces capillary morphogenesis of endothelial cells through Src. |
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Keywords: | α1-Antitrypsin Antithrombin III Proteinase inhibitor 9 LDL-receptor-related protein CD91 CD36 U937 cells Interferon α2 |
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