| Institution: | (1) Second Division of Cardiology, Evangelismos General Hospital, Athens, Greece;(2) Cardiovascular Institute, Michael Reese Hospital, Chicago, Illinois, USA;(3) Division of Cardiology, Michael Reese Hospital, Chicago, Illinois, USA;(4) Division of Pulmonary and Critical Care Medicine, Medical College of Wiskonsin, Milwaukee, Wiskonsin 53226, USA;(5) Abbott Laboratories, Abbott Park, Waukegan, Illinois 60085, USA;(6) Department of Physiology, Michigan State University, East Lansing, Michigan, USA |
| Abstract: | Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas
(CD95, APO1) but other types are resistant. Because heterogeneity among endothelial cells from different tissues, has been
demonstrated, the purpose of this study was to determine, if Fas ligation and/or activation by human Fas ligand induces apoptosis
and caspase activities, in cultured human coronary artery endothelial cells, and the differences between TNF-a and FAS induced
apoptosis in these cells. |
