Poly ADP-ribosylation - A cellular emergency reaction? |
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| Authors: | U Wintersberger E Wintersberger |
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| Institution: | 1. Institute for Tumor Biology/Cancer Research, University of Vienna, A-1090 Vienna, Austria;2. Institute of Molecular Biology, University of Vienna, A-1090 Vienna, Austria |
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| Abstract: | We propose that the activation of poly(ADP-ribose) synthetase by DNA damage serves to decrease rapidly and transiently the cellular level of NAD (by production therefrom of poly ADP-ribose). The result is a slow-down of energy-requiring reactions, in particular of replicative DNA synthesis giving cells more time to repair the damage. We do not attribute any specific role to poly ADP-ribosylated proteins in this reaction beyond their action as acceptors for poly ADP-ribose. |
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