Oxidized low density lipoprotein stimulates aortic smooth muscle cell proliferation |
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| Authors: | Chatterjee Subroto; Ghosh Nupur |
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| Institution: | Lipid Research Atherosclerosis Unit, Johns Hopkins University, School of Medicine Baltimore, MD 21287-3654, USA |
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| Abstract: | We have investigated the effects of oxidized low density lipoproteins(Ox-LDL) on aortic smooth muscle cell (SMC) proliferation andthe biosynthesis of glycosphingo-lipids. We found that Ox-LDL exerted a concentration, time, and temperaturedependent alteration of cell proliferation and the biosynthesisof lactosylceramide. At low concentrations (5–10 µg/mlmedium) Ox-LDL stimulated cell proliferation measured by anincrease in the incorporation of 3H-thymidine in cells and thesynthesis of lactosylceramide, but not glucosylceramide synthesis.Oxidized LDL exerted a threefold increase in the incorporationof 3H]-galactose and 3H]-serine in lactosylceramide. The activityof lactosylceramide synthetase; UDP-galactose glucosylceramideß1 |
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