Alu polymorphism within the MICB gene and association with HLA-B alleles |
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Authors: | Jerzy K Kulski David S Dunn Jennie Hui Patricia Martinez Amornrat V Romphruk Chanvit Leelayuwat Guan K Tay Akira Oka Hidetoshi Inoko |
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Institution: | Centre for Bioinformatics and Biological Computing, School of Information Technology, Murdoch University, Murdoch, 6150 Western Australia, Australia. jkulski@murdoch.edu.au |
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Abstract: | We describe the finding of an Alu repeat dimorphism within the first intron of the MICB gene. The frequencies of the two AluyMICB alleles, AluyMICB*0(absence of insertion) and AluyMICB*1(presence of insertion), and their associations with the highly polymorphic HLA-B locus were determined for 51 human cell lines and for 109 and 200 Caucasians and northeastern Thais, respectively. Analysis of the AluyMICB and HLA-B allelic relationships revealed that AluyMICB*1 occurred at relatively low gene frequency (0.118-0.157) corrected] but was strongly associated with HLA-B17 (HLA-B57,HLA-B58) and HLA-B13. The AluyMICB locus provides a useful dimorphic marker for investigations on the level of linkage disequilibrium between MICB, MICA, and HLA-B loci. |
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