| 低氘水对小鼠免疫调节作用的研究 |
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| 引用本文： | 连璐,丛峰松,蔡东联,曲丹,林宁,王洁.低氘水对小鼠免疫调节作用的研究[J].氨基酸和生物资源,2010,32(3):59-62. |
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| 作者姓名： | 连璐 丛峰松 蔡东联 曲丹 林宁 王洁 |
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| 作者单位： | 第二军医大学长海医院临床营养科,上海,200433;上海交通大学生命科学技术学院,上海,200240 |
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| 摘 要： | 探讨低氘水(deuterium-depleted water,DDW)对小鼠免疫调节的作用。实验组小鼠以低氘水作为饮用水,对照组饮自来水,饲养6周,分别测定免疫蛋白IgG,,IgM的含量,脾脏指数和胸腺指数(mg/g),脾淋巴细胞增殖能力,迟发型变态反应,NK细胞活性以及T细胞亚群CD4+和CD4+/CD8+的变化,观察低氘水对小鼠非特异性免疫和特异性免疫功能的影响。结果低氘水能显著提高IgM,脾脏指数的水平和CD4+,CD4+/CD8+的含量。低氘水对小鼠非特异性免疫和特异性免疫功能具有一定的增强作用。
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| 关 键 词： | 低氘水 IgG IgM 迟发型变态反应 NK细胞活性 CD+4 免疫调节 |
Effect of Deuterium-Depleted Water on Immunomodulation in Mice |
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| LIAN Lu,CONG Feng-song,CAI Dong-lian,QU Dan,LIN Ning,WANG Jie.Effect of Deuterium-Depleted Water on Immunomodulation in Mice[J].Amino Acids & Biotic Resources,2010,32(3):59-62. |
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| Authors: | LIAN Lu CONG Feng-song CAI Dong-lian QU Dan LIN Ning WANG Jie |
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| Institution: | LIAN Lu1,CONG Feng-song2,CAI Dong-lian1,LIN Ning1,QU Dan1,ZHENG Hui1,WANG Jie1(1、Department of Clinical Nutrition,Changhai Hospital,Second Military Medical University,Shanghai 200433;2、College of Life Science And Technology,Shanghai Jiao Tong University,Shanghai 200240,China) |
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| Abstract: | To evaluate the immunomodulating effects of deuterium-depleted water(DDW) on normal mice,all of the mice were divided into 2 groups.One was the experimental group accepted DDW as the water,and another was the control group.After 6 weeks,IgG,IgM,thymus index,spleen index,the proliferation of spleen lymphocytes,the activity of NK cell,CD4+,CD4+/CD8+ and dinitrofluorobenzeneinduced delayed type hypersensitivity test(DTH) were employed to evaluate the immunomodulating effects of DDW on non-specific and specific... |
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| Keywords: | IgG IgM CD+4 |
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