Synthesis of methyl 2- and 4-pyridyl disulfide from 2- and 4-thiopyridone and methyl methanethiosulfonate |
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| Authors: | T M Kitson K M Loomes |
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| Affiliation: | 1. Department of Pharmacy, Biopharmaceutics and Pharmaceutical Technology, Saarland University, 66123 Saarbrücken, Germany;2. Department of Pharmacy, Pharmaceutical Biology, Saarland University, 66123 Saarbrücken, Germany;3. Department of Polymer Chemistry, Saarland University, 66123 Saarbrücken, Germany;4. Saarene, Saarland Center for Energy Materials and Sustainability, 66123 Saarbrücken, Germany;1. Département de Psychiatrie & Neurosciences, Faculté de Médecine, Université Laval, Québec G1V 0A6, QC, Canada;2. Centre de Recherche du CHU de Québec, Québec G1V 4G2, QC, Canada |
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| Abstract: | In 1982, methyl 2-pyridyl disulfide was reported as a new reagent for the titration of thiol groups in peptides and proteins and for their temporary blocking with the thiomethyl group [T. Kimura et al. (1982) Anal. Biochem. 122, 274-282]. We have synthesized this compound (and its 4-pyridyl isomer) by a rapid and convenient procedure which is preferable to that in the original report. Our method involves the thiomethylation of the appropriate thiopyridone by methyl methanethiosulfonate. |
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