Preparation of diazenecarboxamide-carboplatin conjugates by click chemistry |
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| Authors: | Damijana Urankar |
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| Affiliation: | Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ašker?eva 5, SI-1000 Ljubljana, Slovenia |
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| Abstract: | An alternative, mild and highly efficient synthetic approach to platinum complexes with bioactive carrier ligands features a platinum-complex-tolerant copper(I)-catalyzed 1,3-dipolar cycloaddition. As demonstrated by the preparation of novel diazenecarboxamide-carboplatin conjugates, this approach is superior to other methodologies. |
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| Keywords: | Platinum complex Diazenecarboxamide Cycloaddition Click chemistry |
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