| 利用GenMAPP筛查鼻咽癌差异表达基因 |
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| 引用本文： | 周艳宏,张必成,曾朝阳,张文玲,范松青,李小玲,熊 炜,曹 利,李伟芳,李桂源.利用GenMAPP筛查鼻咽癌差异表达基因[J].生物化学与生物物理进展,2005,32(12):1121-1129. |
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| 作者姓名： | 周艳宏 张必成 曾朝阳 张文玲 范松青 李小玲 熊 炜 曹 利 李伟芳 李桂源 |
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| 作者单位： | 中南大学湘雅医学院肿瘤研究所,长沙,410078 |
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| 基金项目： | 国家自然科学基金资助项目(30300205，30300063, 30300201, 30470955, 30330560), 教育部新世纪优秀人才支持计划项目(NCET-04-0761)和湖南省科技厅重大专项(05SK1001-1) |
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| 摘 要： | 利用GenMAPP软件对鼻咽癌和正常鼻咽上皮基因微阵列表达谱结果进行分析，筛查鼻咽癌差异表达基因. 结果显示：在17 000个基因中，与正常鼻咽上皮相比，在鼻咽癌中发生2倍以上差异表达的基因共有339个，其中有160个基因在鼻咽癌中表达上调，179个表达下调. 这些基因分别与细胞增殖、基因转录、凋亡、信号转导、DNA损伤修复、肿瘤分化和浸润转移及细胞周期调节等相关. 鼻咽癌的发生发展存在多基因表达调控的改变，对其差异表达基因的研究有助于阐明鼻咽癌发生发展机制.
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| 关 键 词： | 鼻咽癌，微阵列，基因表达 |
| 收稿时间： | 06 13 2005 12:00AM |
| 修稿时间： | 2005-06-132005-07-28 |
Screening The Differential Expression Genes of Nasopharyngeal Carcinoma Using GenMAPP |
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| ZHOU Yan-Hong,ZHANG Bi-Cheng,ZENG Zhao-Yang,ZHANG Wen-Ling,FAN Song-Qing,LI Xiao-Ling,XIONG Wei,CAO Li,LI Wei-Fang and LI Gui-Yuan.Screening The Differential Expression Genes of Nasopharyngeal Carcinoma Using GenMAPP[J].Progress In Biochemistry and Biophysics,2005,32(12):1121-1129. |
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| Authors: | ZHOU Yan-Hong ZHANG Bi-Cheng ZENG Zhao-Yang ZHANG Wen-Ling FAN Song-Qing LI Xiao-Ling XIONG Wei CAO Li LI Wei-Fang and LI Gui-Yuan |
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| Institution: | Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China;Cancer Research Institute, Xiangya School of Medical, Central South University, Changsha 410078, China |
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| Abstract: | |
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| Keywords: | nasopharyngeal carcinoma microarray gene expression |
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