The inhibition by pertussis and tetanus toxins of evoked catecholamine release from intact and permeabilized bovine adrenal chromaffin cells |
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| Authors: | M K Bansal J H Phillips S van Heyningen |
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| Affiliation: | Department of Biochemistry, University of Edinburgh, UK. |
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| Abstract: | Pertussis toxin stimulates both basal and nicotine-evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca2(+)-evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca2(+)-evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin. |
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