Stimulation of calcitonin secretion in the pig by calcitonin gene-related peptide |
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| Affiliation: | 1. Department of Biosciences, University of Milan, Via Celoria 26, Milan 20133, Italy;2. Department of Chemistry, University of Milan, Via Golgi 19, Milan 20133, Italy;3. CRC Materiali Polimerici “LaMPo”, Department of Chemistry, University of Milan, Via Golgi 19, Milan 20133, Italy;1. Department of Oncological Neurosurgery, First Hospital of Jilin University, Xinmin st No1, Changchun, China;2. Department of Pathology, First Hospital of Jilin University, Xinmin st No1, Changchun City, Jilin Province, China |
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| Abstract: | Pig thyroid glands were surgically isolated in situ and perfused with autologous blood to which was added known concentrations of calcitonin gene-related peptide (αCGRP). When thyroids were perfused with measured concentrations of CGRP within the range of 0.6–600 nM, the secretion rate of calcitonin (CT) was stimulated while the release of T3, T4, and somatostatin remained unchanged. Specific binding of 125I-CGRP to pig thyroid plasma membranes was demonstrated, and binding was inhibited by unlabelled CGRP but not by CT or by other peptides unrelated structurally to CGRP. The findings indicate that the pig thyroid gland contains plasma membrane binding sites for CGRP and that CGRP is capable of stimulating the secretion of CT. |
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