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Molecular genetics of antigenic variation
Affiliation:1. School of Environmental and Rural Science, University of New England, Armidale, NSW, 2351, Australia;2. Agriculture and Food, CSIRO, Armidale, NSW, 2350, Australia;3. School of Life and Environmental Science, Faculty of Veterinary Science, University of Sydney, Sydney, NSW, 2006, Australia;1. Division of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, Columbia University Vagelos College of Physicians and Surgeons, New York, NY;2. Division of Allergy, Immunology, and Rheumatology, Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, NY;3. Division of Rheumatology, Allergy and Immunology, Department of Medicine, Massachusetts General Hospital, Boston, Mass;1. The Francis Crick Institute, Mill Hill Laboratory, The Ridgeway, Mill Hill, London, NW71AA, UK;1. Virus Host Interaction Team, Section of Infection and Immunity, Leeds Institute of Cancer and Pathology, University of Leeds, Leeds LS9 7TF, UK;2. Laboratory of Virology and Chemotherapy, Rega Institute for Medical Research, Department of Immunology and Microbiology, University of Leuven, Leuven, Belgium;3. Division of Infectious Diseases and Vaccinology, School of Public Health, University of California, Berkeley, Berkeley, California, USA
Abstract:Antigenic variation is one of the most effective strategies developed by parasites to escape immune destruction. It requires a large wardrobe of surface coats and mechanisms to exchange one coat for an unrelated one. The molecular principles of antigenic variation are now largely known in the bacterial species Borrelia and Neisseria and in the protozoa of the African trypanosome group and these three examples are discussed here by Piet Borst.
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