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Pump function of the heart as an optimal control problem |
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| Institution: | 1. School of Information Convergence, Kwangwoon University, 20 Kwangwoon-ro, Nowon-gu, Seoul 01897, Republic of Korea;2. Department of Computer Engineering, Korea Polytechnic University, 237, Sangidaehak-ro Siheung-si Gyeonggi-do, Republic of Korea;1. Department of Bioengineering and Aerospace Engineering, Universidad Carlos III, Madrid, Spain;2. Electrical and Computer Engineering, University of British Columbia, Vancouver, Canada |
| Abstract: | In order to model the pump function of the heart the left ventricle is represented as an elastic thick-walled cylinder contracting symmetrically. The acceleration is included in the mathematical formalism describing the contraction of the myocardium and optimal control theory is used to solve the differential equation of motion of the cylindrical wall in such a way as to minimize a given performance index. Application of the equations to experimental data published in the literature is discussed. The mathematical formalism presents a new way to study the time variation of the volume ejected from the left ventricle. Methods to quantify the pump function of the heart are suggested. |
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