Regulation and biological function of helminth-induced cytokine responses |
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| Institution: | 1. School of Pharmacy, University of Auckland, New Zealand;2. Centre for Psychedelic Research, Department of Medicine, Imperial College London, UK;3. Brain Research New Zealand;4. School of Psychology, University of Auckland, New Zealand;5. Department of Anaesthesia and Perioperative Medicine, Auckland District Health Board, New Zealand;6. Department of Psychological Medicine, University of Auckland, New Zealand;1. Centro de Ciencias Biologicas e da Saude, Universidade do Estado do Para, Belem, Para, Brazil 66000-000;2. Nucleo de Medicina Tropical, Universidade Federal do Para, Belem, Para, Brazil 66000-000 |
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| Abstract: | The immunological hallmarks of infection with parasitic belmintbs, namely eosinophilia, mastocytosis and increased IgE synthesis, all appear to be induced by cytokines from the TH2 subset of CD4+ T cells: IgE production is stimulated by interleukin 4 (IL-4), eosinophilia by IL-5 and mastocytosis by IL-3 and IL-4. Here, Fred Finkelman and colleagues argue that the functional significance of the eosinophilia-mastocytosis-IgE axis in helminth infection is unclear and suggest that in some worm infections TH2-cell cytokines may contribute to host protection, while in others they may promote parasite survival. |
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