A dopamine- and octopamine-sensitive adenylate cyclase in the nervous system of Octopus vulgaris |
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| Institution: | 1. School of Anatomical Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, Johannesburg, South Africa;2. Centre for Zoo and Wild Animal Health, Copenhagen Zoo, Fredericksberg, Denmark;3. Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany;1. Marine Science Department, Coastal Carolina University, 301 Allied Drive, Conway, SC 29526, United States;2. Department of Bioengineering, Union College, 807 Union Street, Schenectady, NY 12308, United States;3. Biology Department, Williams College, 59 Lab Campus Drive, Williamstown, MA 01267, United States;4. Program in Sensory Physiology and Behavior, Marine Biological Laboratory, 7 MBL St Woods Hole, MA, United States;5. Department of Integrative Biology and Pharmacology, McGovern Medical School at UTHealth, 6431 Fannin St, Houston, TX, 77030, United States;6. Department of Biology, San Francisco State University, 1600 Holloway Ave, San Francisco CA 94132, United States;1. International College of Arts and Sciences, Fukuoka Women’s University, 1-1-1 Kasumigaoka, Higashi-ku, Fukuoka, 813-8529, Japan;2. Kagawa School of Pharmaceutical Sciences, Tokushima Bunri University, 1314-1 Shido, Sanuki, Kagawa, 769-2193, Japan |
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| Abstract: | - 1.1. Adenylate cyclase activity was assayed in the optic lobe of Octopus vulgaris.
- 2.2. Both octopamine and dopamine stimulate the octopus adenylate cyclase, apparently by competing with the same receptor site.
- 3.3. (±)-2-Amino-6,7-dihydroxy-1,2,3,4-tetrahydronaphthalene-HBr (6,7-ADTN) and a number of phenylethanolamine derivatives stimulate the octopus adenylate cyclase activity.
- 4.4. The dopamine D-1 antagonists R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-HCl (SCH-23390) and (±)-7-bromo-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-HCl (SKF-83566) are unable to antagonize the effects of dopamine and octopamine, and similarly ineffective is the agonist (±)-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol-HCl (SKF-38393).
- 5.5. No detectable binding of labelled SCH-23390 occurs on membrane preparations from octopus optic lobe.
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