Effects of cholinergic and adrenergic agonists on the secretion of fluid and protein by submandibular glands of the hamster and the rat |
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| Affiliation: | 1. Gérontopôle de Toulouse, IHU HealthAge, Institut du Vieillissement, Centre Hospitalo-Universitaire de Toulouse, France;2. CERPOP UMR 1295, University of Toulouse III, Inserm, UPS, Toulouse, France;3. Université de Toulouse III Université Paul Sabatier, Toulouse, France;4. Restore, a geroscience and rejuvenation research center, UMR 1301-Inserm, 5070-CNRS EFS, France.;1. Department of Experimental and Clinical Medicine, Center for the Study of Obesity, Marche Polytechnic University, Ancona, Italy;2. Division of Diabetes, Endocrinology, and Metabolism, Baylor College of Medicine, Houston, TX, USA;3. Center for Translational Research on Inflammatory Diseases, Michael E. DeBakey VA Medical Center, Houston, TX, USA |
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| Abstract: | 1. Significant differences were observed between the hamster and the rat in terms of the secretion of fluid and protein from submandibular glands in response to pilocarpine, phenylephrine and isoproterenol.2. In both the rat and the hamster the secretory responses induced by pilocarpine, phenylephrine and isoproterenol were inhibited by pretreatment with 4-DAMP, prazosin and metoprolol, respectively.3. These results suggest that the submandibular glands of the hamster and the rat have M3-cholino-receptors, as well as α1- and β1-adrenoceptors, and that these receptors play different roles in the secretion of fluid and protein from hamster and rat submandibular glands. |
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